Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed
J. Clin. Invest. Vincent H.J. Leonard, et al. 118:2448 doi:10.1172/JCI35454 [Go to this article.]

Figure 1
Wild-type MV infects human epithelial cells independently of SLAM. (A) Map of the p(+)MV323 plasmid coding for the WT genome and location of the inserted GFP gene. The coding regions of MV genes are represented by arrow-shaped gray boxes. The T7 promoter hepatitis delta virus ribozyme (HδR) and selected unique restriction sites are indicated. The EGFP transcriptional unit was inserted at an EcoRV restriction site downstream of the N gene transcription start. (B) Viral growth kinetics of cell-associated (left) or released (right) WT_green following infection of H358 (triangles), Vero/hSLAM (squares), or Vero (diamonds) cells. Viral titers (mean of 2 measurements) are indicated as TCID₅₀/ml.