Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed
J. Clin. Invest. Vincent H.J. Leonard, et al. 118:2448 doi:10.1172/JCI35454 [
Go to this article.]
Figure 4Growth kinetics of an EpR-blind MV and analysis of its virulence in rhesus macaques. (
A) Kinetics of the production of cell-associated (top) or released (bottom) WT (squares) and WT-H
DOUBLE (triangles) in Vero/hSLAM cells. Viral titers are indicated as TCID
50/ml. Error bars indicate mean ± SD;
n = 3. (
B) Titration of viremia in blood samples taken on days 7 or 14 after inoculation of 6 animals infected with 10
4.5 TCID
50 WT-H
DOUBLE (WT-H
D). Each dot represents 1 animal; the mean for the group is indicated by a horizontal bar. The dashed line represents the limit of detection. Data for WT infections are from ref.
29. (
C) Neutralizing antibody response. Sera obtained at 0, 14, and 28 days after inoculation were assayed for MV neutralization, and results are presented as reciprocals of the titer. Each dot represents an animal. Data for infections with WT are from ref.
29.
