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The JCI is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.

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Cover story: Leptin-mediated brain responses to weight loss
Why do those who lose weight eventually gain it back? Rosenbaum and colleagues use functional magnetic resonance imaging to examine the effects of weight loss and leptin on neural activity (page 2583). They found alterations in neural activity in response to visual food cues in regions of the brain known to control regulatory and hedonic aspects of energy intake. These changes in neural activity during maintenance of a reduced weight were due substantially to central leptin deficiency.
Image credit: Photo Researchers Inc. (brain section) and Karen Guth (grapes).
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Global Health
Series funded by an unrestricted educational grant from the Bill and Melinda Gates Foundation
Although advances in science and technology have resulted in substantial improvements in the health of individuals in the developed world, similar progress has not been observed for those living in the developing world. This Review Series focuses on the health conditions that affect people living in the developing world, and it highlights some of the areas that require attention if these conditions are either to be brought under control or eradicated.
Molecular Mechanisms of Stress
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Kitty B.J.M. Cleutjens, Birgit C.G. Faber, Mat Rousch, Ruben van Doorn, Tilman M. Hackeng, Cornelis Vink, Piet Geusens, Hugo ten Cate, Johannes Waltenberger, Vadim Tchaikovski, Marc Lobbes, Veerle Somers, Anneke Sijbers, Darcey Black, Peter J.E.H.M. Kitslaar, and Mat J.A.P. Daemen
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Helicobacter pylori eradication shifts monocyte Fcγ receptor balance toward inhibitory FcγRIIB in immune thrombocytopenic purpura patients
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Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I
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Immune response hinders therapy for lysosomal storage diseases
Katherine P. Ponder
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Marc Martínez-Llordella, Juan José Lozano, Isabel Puig-Pey, Giuseppe Orlando, Giuseppe Tisone, Jan Lerut, Carlos Benítez, Jose Antonio Pons, Pascual Parrilla, Pablo Ramírez, Miquel Bruguera, Antoni Rimola, and Alberto Sánchez-Fueyo
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Fifty years later: the disk goes to the prom
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