ResearchIn-Press PreviewGeneticsOphthalmology
Open Access | 
10.1172/jci.insight.209108
Allotopic Expression of ND6 Restores Vision in a Mitochondrial Disease Model
Cheng Ai,1 Huiying Li,1 Jing Wu,1 Tianwei Zhou,1 Jing Wang,2 Shao-Hui Pan,3 Jun Yu,1 Douglas C. Wallace,4 and Min-Xin Guan1
1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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Li, H.
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
Find articles by Yu, J. in: PubMed | Google Scholar
1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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1Center for Mitochondrial Biomedicine and Department of Ophthalmology, Fourth Affiliated Hospital of School of Medicine, Yiwu, China
2Institute of Genetics, Zhejiang University, Hangzhou, China
3Hangzhou Institute of Medicine, Wenzhou Medical University, Hangzhou, China
4Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, United States of America
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Guan, M.
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Published September 8, 2026 - More info
Copyright © 2026, Ai et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
