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Research LetterIn-Press PreviewCell biologyPulmonology Open Access | 10.1172/jci.insight.206375

Basal cell transplantation supports multilineage differentiation and restores CFTR function in ex vivo ferret airways

Kadambari Vijaykumar,1 Liang Ma,2 Kevin Chen,2 Liping Tang,1 Nikoleta Pavelkova,1 Elex Harris,1 Kajal Jadhav,1 Qian Li,1 Mohamed Hanafy,1 Hinnerk Schulz-Hildebrandt,3 Guillermo J. Tearney,3 Finn Hawkins,2 Darrell N. Kotton,2 and Steven M. Rowe1

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Vijaykumar, K. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Ma, L. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Chen, K. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Tang, L. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Pavelkova, N. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Harris, E. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Jadhav, K. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Li, Q. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Hanafy, M. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Schulz-Hildebrandt, H. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Tearney, G. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Hawkins, F. in: PubMed | Google Scholar

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Kotton, D. in: PubMed | Google Scholar |

1Department of Medicine and Gregory Fleming James Cystic Fibrosis Research C, University of Alabama at Birmingham, Birmingham, United States of America

2Center for Regenerative Medicine, Boston Medical Center, Boston, United States of America

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States of America

Find articles by Rowe, S. in: PubMed | Google Scholar |

Published August 18, 2026 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.206375.
Copyright © 2026, Vijaykumar et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published August 18, 2026 - Version history
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