ResearchIn-Press PreviewAIDS/HIVImmunologyInfectious disease
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10.1172/jci.insight.201268
The pleural tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control
Samantha Cronin,1 Jennifer Simpson,1 Andrea Pereyra-Casanova,1 Yuchen Li,1 Josefina Marín-Rojas,2 Freja A. Warner van Dijk,1 Katie Fisher,1 Daniel J. Buffa,1 Hafsa Rana,1 Zoï Vahlas,3 Joaquina Barros,4 Mariano Maio,4 Thomas R. O'Neil,1 Kirstie M. Bertram,1 Eunok Lee,1 Najla Nasr,1 Andrew N. Harman,1 Gabriela Turk,4 Maria Florencia Quiroga,4 Anthony D. Kelleher,7 Christel Vérollet,8 Luciana Balboa,4 Sarah Palmer,1 and Gabriel Duette1
1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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1Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, Australia
2Centre for Virus Research, The Wesmtead Institute for Medical Research, Sydney, Australia
3Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS. Université Toulouse III - Paul Sabatier (UT3), Toulouse, France
4Departamento de Microbiología, Parasitología e Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
5Centre for Virus Research, The Westmead Institute for Medical Research, Australia
6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
7The Kirby Institute, University of New South Wales, Sydney, Australia
8Mécanismes Moléculaires des Infections Mycobactériennes, CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
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Published August 20, 2026 - More info
Copyright © 2026, Cronin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
